ATF2 in transcription and DNA damage

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ATF2 - a HLH bZIP transcription factor mediates its transcriptional functions upon its heterodimerization with other members of the bZIP family, as primarily demonstrated for c-Jun. For its transcriptional function, ATF2 needs to be phosphorylated by JNK or p38, on N-terminal residues. We found that ATF2 is also subject to modification by ATM (and possibly other members of the PIKK family), whereby it is recruited to DNA damage repair foci (MRN complex) within a few minutes after exposure to DNA damage. ATF2 phosphorylation by ATM occurs on its C-terminal end and is independent of JNK/p38 activities. This study was published in the journal Molecular Cell in 2005.

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