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	About the Institute » Faculty

ANDREI OSTERMAN, PH.D.

Associate Professor

Bioinformatics & Systems Biology

osterman@burnham.org

858.646.3100 x3564 (phone)

858.713.9930 (fax)

RESEARCH FOCUS, BIOGRAPHY, PUBLICATIONS

Research Focus

The research team led by Dr. Andrei Osterman, pioneered the use of genome context analysis and metabolic reconstruction technology to predict previously uncharacterized (“missing”) genes in metabolic pathways. Many of these functional predictions were verified by direct biochemical and genetic experiments, including identification and characterization of several key enzymes in metabolism of NAD, FAD and CoA cofactors. This group also performed an genome-wide experimental determination and a systems level analysis of essential genes in the model of E.coli. Currently Dr. Osterman is continuing his discovery-oriented work at the interface of experimental and computational biology, expanding his interests towards human and cancer biology. He is supervising the work of the Informatics and Data Management Shared Resource providing the bioinofrmatics support for a variety of research projects at the Burnham Institute Cancer Center. Andrei Osterman is one of the founders of the new research organization, the Fellowship for the Interpretation of Genomes (the FIG, Chicago, IL). The FIG, in collaboration with Argonne National Laboratory is pursuing the "Project to annotate 1,000 genomes" and the SEED, a powerful genomic integration platform supporting this community-based effort. Participation in this development brings to the Burnham Institute a strategically important collaboration and an access to a new generation of biocomputational software.

Biography

Dr. Andrei Osterman joined the developing Program in Bioinformatics and Systems Biology of the Cancer Center at the Burnham Institute as an Associate Professor in August 2003. He received his doctorate from Moscow State University in 1983, did postdoctoral work UT Southwestern Medical Center, and held the position of the Director and then Vice President of Research at Integrated Genomics in 1999-2003.

Selected Publications

Gerdes, S. Y., M. D. Scholle, J. W. Campbell, G. Balazsi, E. Ravasz, M. D. Daugherty, A. L. Somera, N. C. Kyrpides, I. Anderson, M. S. Gelfand, A. Bhattacharya, V. Kapatral, M. D'Souza, M. V. Baev, Y. Grechkin, F. Mseeh, M. Y. Fonstein, R. Overbeek, A. L. Barabasi, Z. N. Oltvai, and A. L. Osterman. (2003). Experimental determination and system level analysis of essential genes in Escherichia coli MG1655. J Bacteriol 185:5673-84.

Kurnasov, O., V. Goral, K. Colabroy, S. Gerdes, S. Anantha, A. Osterman, and T. P. Begley. (2003). NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria. Chem Biol 10:1195-204.

Kurnasov, O., L. Jablonski, B. Polanuyer, P. Dorrestein, T. Begley, and A. Osterman. (2003). Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. FEMS Microbiol Lett 227:219-27.

Osterman, A. & Overbeek R. (2003) “Missing genes in metabolic pathways: A comparative genomics approach.” Current Opin. Chem. Biol. 7, 1-14.

Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N.V., Osterman, A.L. & Zhang, H. (2003) Crystal structure of human riboflavin kinase reveals a barrel fold and a novel active site arch. Structure 11, 265-273.

Kurnasov O., Polanuyer B., Ananta S, Sloutsky R., Tam A., Gerdes S., and Osterman A. (2002), “Ribosylnicotinamide Kinase Domain of NadR Protein: Identification and Implications in NAD Biosynthesis”, Bacteriol. 2002 Dec;184(24):6906-17.

Daugherty M., Polanuyer B., Farrell M., Lykidis A., de Crécy-Lagard V., and Osterman A. (2002), “Human Coenzyme A Biosynthesis: Complete Pathway Reconstitution Via Comparative Genomics”, J Biol Chem.; v.277(24):21431-9.

Gerdes, S., Scholle, M., D'Souza, M., Bernal, A., Baev, M., Farrell, M.,Kurnasov, O., Daugherty, M., Mseeh, F., Polanuyer, B., Campbell, J., Anantha, S., Shatalin, K., Chowdhury, S., Fonstein, M. and Osterman, A. (2002), “From Genetic Footprinting to Antimicrobial Drug Targets: Examples in Cofactor Biosynthetic Pathways”, J.Bacteriology, v.184, (16), p.4555-72.

Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A. & Zhang, H. (2002). Structure of human NMN/NaMN adenylyltransferase: basis for the dual substrate specificity and activation of anticancer drug tiazofurin. J. Biol. Chem. 277, 13148-54.

Zhang H., Zhou T., Kurnasov O., Cheek S., Grishin N., and Osterman A. (2002) “Crystal Structures of E. coli Nicotinate Mononucleotide Adenylyltransferase and its Complex with Deamido-NAD”, Structure, v.10, p.69-79.

M. Daugherty, V. Vonstein, R. Overbeek, and A. Osterman (2001), “Archaeal Shikimate Kinase: A New Member of the GHMP-Kinase Family”, J. Bacteriology, v.183 (1), p.292-300.